Phase 1 clinical trials

Contact: [email protected]

* Studie on hold of geen beschikbare plaatsen

TitleTumor typeLineStudy information
EZH-1201All>SOCModerate hepatic: bili 1.5 to 3xULN; Severe hepatic: bili >=3xULN; PK study tazemetostat
TRIDENT-1 NTRKAllOral repotrectinib
BT5528-100*Urothelial>SOCBicyclic peptide (EphA2 + MMAE)
CodeBreak 101 (20190135)*KRASG12C>1LSotorasib + FOLFIRI + Pmab; CRC
20210023MTAP loss>SOCMTAP Expression central; oral AMG193 (PRMT5 inhibitor), sq. lung, BTC
Fortitude-301 (20210104)NSCLC only adenoca.SeveralFGFR2b+; Bemarituzumab (AMG552)
WP43295*BRAFV600>SOCSolid tumors with BRAF (mono or combo); RO7276389
ORIGAMI-1*CRC (wt)2LAnti-EGFR+MET; chemo + amivantamab
MK6482-016ESCCSeveralPembrolizumab + Lenvatinib (anti-VEGFR1-3) + Belzutifan (anti-HIF2α)
DO2.22.01MET>SOCMET mutation / MET ampl (>10GCN); DO-2 oral
Brightline-2 (BI1403-0011)MDM2 ampl>SOCBI907828 oral (MDM2-p53 antagonist); TP53wt; lung adenoca
BI1456-0001All solid>SOCBI 1831169 oncolytical virus VSV-GP intratumoral
GO43860HNSCC, GC>SOCRO7502175 Anti-CCR8 + Atezolizumab
PYX-201-101*Multiple>SOCPYX-201: Ab-drug conjug (anti-EDB+fibronectin+auristatin); NSCLC/HNSCC/Ovar/Breast/PDAC/Sarc/Uro/Thyroid
IMC-F106C-101HLA+PRAME>SOCIMC-F106C: Anti-CD3+Tcell receptor; mono or combo; Cut. Melan/Uterine/Endom/NSCLC
Bayer 21820GC/GEJ, melanoma>SOCBAY3375968: Anti-CCR8 Ab +/- pembro
SC201 (VICTORIA-01)All solid, without liver m+>SOCSOT201: Fusion protein, PD-1 targeted IL-15 agonist
Bayer 21948Melanoma, NSCLC, RCC, GC, GEJ>SOCBAY 2965501: DGKz inhibitor
U31402-277 (HERTHENA-PanTumor01)HNSCC, cut. melanomaSeveralU3-1402: Patritumab Deruxtecan (HER3-DXd), IV, Q3W
BI1438-0007 (DAREON-7)*NEC1LBI764532 + etoposide + platinum in DLL3+
IL15 TransDC*Pancreas>1LIL15 TransDC vaccin (6 vaccinations, concomitant anti-cancer therapy possible 7D after V2)
CDR404-001HLA+MAGE-A4>SOCCDR404: MHC specific T-cell engager

Research Team