Digestive oncology trials

Contact: [email protected]

* Studie on hold of geen beschikbare plaatsen

TitleTumor typeLineStudy information
ReginaRectalNeoadjuvantRegorafenib + nivolumab + short course RT in intermediate risk stage II-III
AZUR-2CRCNeoadjuvantRand. study of perioperative Dostarlimab mono vs. SOC (surgery + adj chemo) in T4N0 or Stage III dMMR/MSI-H resectable CRC
IMCODE003 (GO44479)*PancreasAdjuvantAutogen cevumeran IV + atezo + mFOLFIRINOX vs. mFOLFIRINOX; screening before surgery
NalpacPancreas2LNaliri vs Nalirinox. PD after 1st line gemcitabine mono or gem/abraxane
StereopacPancreasNeoadjuvantpreop mFOLFIRINOX (or gem/NabP) +/- SBRT in borderline resectable
Mountaineer-03
(SGNTUC-029)
CRC1LTucatinib+trastuzumab + mFOLFOX6 vs. mFOLFOX6 +/- bevacizumab/cetuximab in HER2+, RAS wt CRC
Imbrave152HCC1LTiragolumab (anit-TIGIT) vs. placebo + atezolizumab + bevacizumab
REPLACE
(TRIO 041)
HCC1LRegorafenib + pembrolizumab vs. TACE or TARE
TT420C2308
(FIRST-308)*
Cholangio>1LTinengotinib (PO) vs. Physician’s choice therapy; prior FGFR inhibitor required
BI1438-0007
(DAREON-7)
NEC 1LBI764532 + etoposide + platinum in DLL3+ (phase 1)
IL15 TransDCPancreas>1LIL15 TransDC vaccin (6 vaccinations, concomitant anti-cancer therapy possible 7D after V2; phase 1)